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US 12,275,772 B2Granted
ROR-1 specific chimeric antigen receptors and uses thereof
AssigneePrecigen, Inc.
InventorsRutul R. Shah, ChangHung Chen, Cheryl G. Bolinger, Vinodhbabu Kurella, Amy Wesa
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Abstract
Provided herein are chimeric antigen receptors (CARs) for cancer therapy, and more particularly, CARs containing a scFv from an anti-ROR-1 monoclonal antibody. Provided are immune effector cells containing such CARs, and methods of treating proliferative disorders.
Claims58
A nucleic acid encoding a chimeric antigen receptor (CAR), comprising:
- (a) a ROR-1 antigen binding domain comprising:
- (i) a first polypeptide comprising the an amino acid sequence of SEQ ID NO:
- 36;
- and (ii) a second polypeptide comprising the amino acid sequence of SEQ ID NO:
- 17;
- (b) a transmembrane domain;
- and
- (c) a CD3 zeta signaling domain.
5 more elements
Dependencies are inferred from the claim text.