Class of phosphine nitrogen ligand with multiple chiral centers and its synthesis method and application

A method for the synthesis of a class of phosphine nitrogen ligand with multiple chiral centers, wherein, the phosphine nitrogen ligand is obtained by the following steps:

• (1) in the solvent, 3,6-dichloro-4,5-dimethylpyridazine and borate ester compounds are taken as raw materials to react to obtain the biaryl compounds, in the presence of base, with palladium salt and phosphine ligand as catalytic system or directly using palladium and phosphine complexes;
• (2) in the solvent, the biaryl compounds obtained in step (1) and chiral amine are taken as raw materials, in the presence of a base, with palladium salt and phosphine ligand as catalytic system or directly using palladium and phosphine complexes to obtain the amination product through coupling reaction;
• (3) in the solvent, the amination product obtained in step (2) reacts with the acid to obtain the phenolic products;
• (4) in an organic solvent, in the presence of an acid binding agent, the phenolic products obtained in step (3), trifluoromethanesulfonation reagent and 4-dimethylaminopyridine react to obtain the trifluoromethanesulfonation products;
• (5) in an organic solvent, the trifluoromethanesulfonation product obtained in step (4), diphenylphosphine, nickel and an organic base react to obtain the phosphine nitrogen ligand with multiple chiral centers;
• the reaction process has the following reaction equation (A):
• wherein,
• represents the chiral centers.