Back to results
US 12,275,740 B2Granted
Method of inhibiting kinase by camsylate salts of triazolopyrazine derivatives
OwnerJun Young Choi, Kyung-eui Park +1inventors
InventorsJun Young Choi, Kyung-eui Park, Na Young Kim
Life of this patent
Estimating the term…
Abstract
Disclosed are a salt (camsylate salt) of D(+)-10-camphorsulfonic acid and a triazolopyrazine derivative of formula (1), pharmaceutical compositions thereof, methods of making the salt, and therapeutic use thereof:
Claims5
A method of inhibiting the activity of c-Met kinase in a subject comprising administering to the subject in need thereof a therapeutically effective amount of a camsylate salt of the compound of formula (1):
- wherein the camsylate salt has an HT-XRPD pattern with characteristic peaks corresponding substantially to:
- 2θ [°]
- d [Å]
- Intensity
- or
- 2θ [°]
- d [Å]
- Intensity
- 1
- 6.29
- 14.04
- 31
- 1
- 6.34
- 13.92
- 22
- 2
- 10.31
- 8.57
- 38
- 2
- 10.36
- 8.53
- 28
- 3
- 12.20
- 7.25
- 45
- 3
- 12.03
- 7.35
- 28
- 4
- 13.70
- 6.46
- 41
- 4
- 12.26
- 7.21
- 28
- 5
- 14.32
- 6.18
- 94
- 5
- 13.80
- 6.41
- 42
- 6
- 15.54
- 5.70
- 60
- 6
- 14.33
- 6.18
- 100
- 7
- 16.92
- 5.24
- 100
- 7
- 14.94
- 5.92
- 39
- 8
- 18.19
- 4.87
- 35
- 8
- 15.52
- 5.70
- 46
- 9
- 20.12
- 4.41
- 46
- 9
- 16.83
- 5.26
- 72
- 10
- 21.57
- 4.12
- 43
- 10
- 18.26
- 4.85
- 27
- 11
- 23.36
- 3.81
- 31
- 11
- 20.11
- 4.41
- 33
- 12
- 24.19
- 3.68
- 37
- 12
- 21.14
- 4.20
- 25
- 13
- 26.46
- 3.37
- 26
- 13
- 21.42
- 4.14
- 28
- 14
- 27.79
- 3.21
- 23
- 14
- 22.35
- 3.98
- 21
- 15
- 28.84
- 3.09
- 21
- 15
- 23.42
- 3.80
- 24
- 16
- 29.50
- 3.03
- 22
- 16
- 23.92
- 3.72
- 24
- 17
- 26.38
- 3.38
- 18
- 18
- 27.92
- 3.19
- 16
- 19
- 28.83
- 3.09
- 19
- 20
- 29.59
- 3.02
- 15.
149 more elements
Dependencies are inferred from the claim text.