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US 12,275,685 B2Granted
Oligo-benzamide analogs and their use in cancer treatment
AssigneeBoard of Regents, The University of Texas System
InventorsGanesh Raj, Jung-Mo Ahn, Ratna K. Vadlamudi
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Abstract
The present disclosure compounds of the formulae: wherein the variables are defined herein, as well as pharmaceutical compositions thereof. The present disclosure also provides methods for the use of said compounds and/or pharmaceutical compositions, such as in the treatment of cancer.
Claims33
A compound of the formula:
- wherein:
- R1 is halo, —NO2, alkyl(C≤12), substituted alkyl(C≤12), amido(C≤12), substituted amido(C≤12), or —NHC(O)CH(R1a)NH2, wherein:
- R1a is aralkyl(C≤18), substituted aralkyl(C≤18), or the side chain of a canonical amino acid;
- R2, R3, and R4 are each independently alkyl(C≤12), substituted alkyl(C≤12), aralkyl(C≤18), or substituted aralkyl(C≤18);
- and
- R5 is —NHR5b, wherein:
- R5b is
- cycloalkyl(C≤12), or heteroaryl(C≤12), or a substituted version of these groups;
- or
- a group of the formula:
- wherein:
- L1 is —C(O)NRL1—, wherein:
- RL1 is hydrogen, alkyl(C≤12), or substituted alkyl(C≤12);
- R5b′ is aryl(C≤12), aralkyl(C≤18), heteroaryl(C≤12), heteroaralkyl(C≤18), or a substituted version of any of these groups;
- or a pharmaceutically acceptable salt thereof.
12 more elements
Dependencies are inferred from the claim text.