Particulate poly(lactic-co-glycolic) acid, method for manufacturing particulate poly (lactic-co-glycolic) acid, and particulate poly(lactic-co-glycolic) acid manufacturing apparatus

A method for manufacturing particulate poly(lactic-co-glycolic) acid (PLGA), comprising:

• dissolving a poly(lactic-co-glycolic) acid (PLGA) in a solvent consisting of a good solvent of the PLGA to obtain a PLGA solution;
• discharging the PLGA solution from at least one discharge hole having an inner diameter of less than 1.0 mm into a poor solvent of the PLGA;
• and
• forming particulate PLGA having an average volume-based particle diameter of 80 nm or less and a relative span factor (R.S.F.) satisfying the following Formula (I):
• 0<R.S.F.≤1.2 Formula (I),
• wherein said good solvent has a PLGA solubility of 0.1 g or more per 100 g of solvent at 25° C., and said poor solvent has a PLGA solubility of at most 0.05 g per 100 g of solvent at 25° C.,
• said method is an emulsion solvent diffusion method and,
• discharging of said solution is performed in a liquid discharger equipped with the at least one discharge hole, a liquid chamber and a vibration generator which applied a vibration to said liquid chamber to cause said PLGA solution to be discharged from said at least one discharge hole.