Cosmetic compositions and methods of use
AssigneeK&K Biotech
InventorsKristina Trujillo, Katie Uilk
Life of this patent
Estimating the term…
Abstract
The present invention relates to substituted stilbenes and dienones which exhibit unexpected dual activity, as inhibitors of NFκB and as agonists (activators) of Nrf2. In particular, these compounds show dual activity and it has been discovered that these compounds are particularly useful in the treatment of certain cosmetic applications and in rejuvenating and beautifying skin and other keratinous tissue of a subject in need. Cosmetic compositions and methods of using said compositions in combination with other components are disclosed herein.
Claims17
A method of treating a cosmetic condition of the keratinous tissue of a subject comprising administering to the subject a composition comprising an effective amount of at least one compound which exhibits dual activity as a NF-KB signaling inhibitor and a Nrf2 signaling agonist, in combination with at least one cosmetic additive, wherein the compound comprises at least one structure selected from the group consisting of:
- stilbene which contains at least one substitute on at least one of the aryl rings;
- dienone;
- and
- 3-hydroxy-1,3-diphenylprop-2-en-1-one,
- wherein the cosmetic condition of the keratinous tissue of the subject comprises at least one condition selected from the group consisting of acne scars, stretch marks, and wrinkles.
A cosmetic composition for use in the treatment of at least one cosmetic condition of the keratinous tissue selected from the group consisting of acne scars, stretch marks, and wrinkles, the composition comprising an effective amount of at least one compound which must exhibit at least dual activity as a NF-KB signaling inhibitor and a Nrf2 signaling agonist in combination with at least one additional cosmetic additive, wherein the compound at least one structure selected from the group consisting of:
- stilbene which contains at least one substitute on at least one of the aryl rings;
- dienone;
- and
- 3-hydroxy-1,3-diphenylprop-2-en-1-one.
Dependencies are inferred from the claim text.