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US 12,274,758 B2Granted
Guide RNA that targets a mutant human inosine monophosphate deyhydrogenase I allele
AssigneeEmendoBio Inc.
InventorsLior Izhar, David Baram, Joe Georgeson, Michal Golan-Mashiach, Asael Herman, Rafi Emmanuel
Life of this patent
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Abstract
RNA molecules comprising a guide sequence portion having 17-20 nucleotides in the sequence of 17-20 contiguous nucleotides set forth in any one of SEQ ID NOs: 1-3010 and compositions, methods, and uses thereof.
Claims6
An isolated guide RNA (gRNA) that targets a mutant Inosine Monophosphate Dehydrogenase 1 (IMPDH1) allele, wherein the gRNA comprises a CRISPR RNA (crRNA) consisting of the nucleic acid sequence of SEQ ID NO:
- 159, 160, 161, 274, 276, 282, 3011, 3012, 3013, 3014, or 3015.
Dependencies are inferred from the claim text.