Recombinant adeno-associated viruses encoding serpin peptides and uses thereof
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsAlexandra Rose Lucas, Alfred S. Lewin, Cristhian J. Ildefonso
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Abstract
In some aspects, the disclosure relates to compositions and methods that are useful for treating inflammatory disorders and conditions. In some embodiments, the disclosure provides recombinant adeno-associated virus (rAAV) vectors and particles encoding a transgene that expresses a Myxomavirus serine proteinase inhibitor (Serp) protein (e.g., Serp-1) and methods for treating inflammatory disorders using the same.
Claims15
A recombinant adeno-associated virus (rAAV) vector comprising an isolated nucleic acid encoding a serine proteinase inhibitor 1 (Serp-1) peptide, flanked by two adeno-associated virus (AAV) inverted terminal repeat (ITR) sequences, wherein the rAAV vector comprises the nucleic acid sequence set forth in any one of SEQ ID NOs:
- 2-4.
Dependencies are inferred from the claim text.