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US 12,274,725 B2Granted
Zika virus strains for treatment of glioma
AssigneesWashington University, The Cleveland Clinic Foundation, Board of Regents, The University of Texas System
InventorsMichael Diamond, Milan Chheda, Jeremy Rich, Pei-Yong Shi, Zhe Zhu, Matthew Gorman
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Abstract
The present disclosure involves a composition and method of treatment of glioblastoma, using ZIKA virus.
Claims4
A method of treating a glioma in a subject in need thereof, the method comprising:
- intratumorally administering a composition comprising an engineered ZIKV to the subject, wherein the engineered ZIKV comprises a 10 nucleotide deletion in the 3′ UTR of the ZIKV genome, wherein the 10 nucleotide deletion disrupts short flaviviral RNA production by the engineered ZIKV as compared to a ZIKV without the 10 nucleotide deletion, wherein (a) the ZIKV is strain FSS13025 comprising the sequence of SEQ ID NO:
- 21 and the deletion comprises nucleotides 10650 to 10659 of SEQ ID NO:
- 21;
- or (b) the ZIKV is strain Dakar 41525 comprising the sequence of SEQ ID NO:
- 22 and the deletion comprises nucleotides 10649 to 10658 of SEQ ID NO:
- 22.
3 more elements
Dependencies are inferred from the claim text.