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US 12,270,809 B2Granted
Method for the site-specific covalent cross-linking of antibodies to surfaces
AssigneeThe Trustees of the University of Pennsylvania
InventorsAndrew Tsourkas, James Z Hui
Life of this patent
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Abstract
This invention relates to conjugate antibody, drug and nanoparticle compositions and methods of generating the same. This invention further relates to methods of using same for imaging, diagnosing or treating a disease.
Claims25
A conjugate composition comprising a variant of protein Z comprising a photoreactive crosslinker that permits specific binding to an immunoglobulin Fc region, wherein the variant of protein Z comprises an amino acid sequence about sixty-one amino acids in length and which has at least 80% identity to the sequence set forth in SEQ ID NO:
- 1 with the photoreactive crosslinker substituted for or introduced at F13, Q32, K35, N28, N23, or L17.
Dependencies are inferred from the claim text.