Nano-engineered therapeutic stealth cells
AssigneeOhio State Innovation Foundation
InventorsDaniel Gallego-Perez, William Carson, Silvia M. Duarte Sanmiguel, Natalia Higuita-Castro
Life of this patent
Estimating the term…
Abstract
Disclosed herein is a method of “reprogramming” highly motile cells found in tumors, such as these highly motile GSC and/or MDSC clones, into “auto-destructive” cell “missiles” (referred to herein as therapeutic stealth cells) that can seek and destroy new foci of recurrence within the body, such as the brain. Cells with enhanced motility can be sorted out from heterogeneous populations and then be rendered “auto-destructive” by deterministic delivery of an anti-cancer agent, such as an oncolytic virus plasmid cocktail.
Claims10
A method for producing a therapeutic stealth cell, comprising (a) sorting myeloid-derived suppressor cells (MDSCs) from a sample from a subject for a subpopulation of the granulocytic CD11b+Ly6CloLy6G+ MDSCs;
- and (b) reprogramming the subpopulation of MDSCs to deliver anti-cancer agents.
Dependencies are inferred from the claim text.