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AssigneeShenzhen Bluepha Biosciences Co., Ltd.
InventorsJin Yin, Yu Wang, Jiajia Li, Jie Hou, Liang Zou, Zixian Chen
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The present invention relates to the technical field of microorganisms, and specifically to engineered microorganisms expressing acetoacetyl-CoA reductase variants and methods for increasing the proportion of 3-hydroxyhexanoic acid in PHA. The acetoacetyl-CoA reductase variants and their coding genes provided by the present invention can significantly increase the proportion of 3-hydroxyhexanoic acid in PHA produced by strains; the proportion of 3-hydroxyhexanoic acid in PHA produced by the engineered Ralstonia eutropha constructed utilizing the acetoacetyl-CoA reductase variants and their coding genes provided by the present invention is significantly increased, which provides new genes and strain resources for strains producing poly(3-hydroxybutyrate-co-3-10 the development of engineered hydroxyhexanoate) with high proportion of 3-hydroxyhexanoic acid.
An engineered Ralstonia eutropha strain, wherein the engineered Ralstonia eutropha strain expresses an acetoacetyl-CoA reductase variant, the acetoacetyl-CoA reductase variant having the amino acid sequence of SEQ ID NO. 10.
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