Antibody specifically binding to ICAM-1 and use thereof
AssigneeKumho Ht, Inc.
InventorsYoo Ri Moon, Gil Yong Ji, Sangsoon Yoon, Jung Sik Kim
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Abstract
The present invention relates to an anti-ICAM-1 antibody or an antigen-binding fragment thereof that specifically binds to ICAM-1, and the use thereof. Specifically, provided are an anti-ICAM-1 antibody or an antigen-binding fragment thereof, a pharmaceutical composition for regulating differentiation and/or function of dendritic cell, and a pharmaceutical composition for preventing and/or treating immune cell-mediated disease, the composition comprising the antibody or the antigen-binding fragment as an active ingredient.
Claims10
An anti-ICAM-1 antibody or an antigen-binding fragment thereof, comprising the following complementarity determining regions (CDRs):
- CDR-H1 comprising the amino acid sequence of SEQ ID NO:
- 1,
- CDR-H2 comprising the amino acid sequence of SEQ ID NO:
- 2,
- CDR-H3 comprising the amino acid sequence of SEQ ID NO:
- 3,
- CDR-L1 comprising the amino acid sequence of SEQ ID NO:
- 4,
- CDR-L2 comprising the amino acid sequence of SEQ ID NO:
- 5, and
- CDR-L3 comprising the amino acid sequence of SEQ ID NO:
- 6,
- wherein the anti-ICAM-1 antibody or an antigen-binding fragment thereof comprises
- a heavy chain variable region comprising the amino acid sequence of SEQ ID NOs:
- 27;
- and
- a light chain variable region comprising the amino acid sequence of SEQ ID NOs:
- 35 or 38.
A nucleic acid molecule encoding
- the amino acid sequence of SEQ ID NO:
- 27;
- and
- the amino acid sequence of SEQ ID NOs:
- 35 or 38.
Dependencies are inferred from the claim text.