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US 12,269,872 B2Granted
Neutralizing antibodies to Plasmodium falciparum circumsporozoite protein and their use
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsRobert Seder, Lawrence Wang, Rachel Vistein, Joseph Francica
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Abstract
Antibodies and antigen binding fragments that specifically bind to P. falciparum circumsporozoite protein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. The disclosed antibodies, antigen binding fragments, nucleic acids and vectors can be used, for example, to inhibit a P. falciparum infection.
Claims31
An isolated monoclonal antibody or an antigen binding fragment thereof, comprising:
- a heavy chain variable region and a light chain variable region comprising a heavy chain complementarity determining region (HCDR) 1, a HCDR2, and a HCDR3, and a light chain complementarity determining region (LCDR) 1, a LCDR2, and a LCDR3 of the VH and VL set forth as SEQ ID NOs:
- 1 and 2, respectively;
- and
- wherein the monoclonal antibody specifically binds to P. falciparum circumsporozoite protein (PfCSP) and neutralizes P. falciparum.
1 more element
Dependencies are inferred from the claim text.