Protein tyrosine-tyrosine analogs and methods of using the same
AssigneeEli Lilly and Company
InventorsDaniel Anthony Briere, Daniel Christopher Lopes, Avinash Muppidi
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Abstract
PYY analogs are disclosed that include modifications that increase half-life when compared to native, human PYY, as well as additional modifications that increase potency and selectivity to the NPY2 receptor. Pharmaceutical compositions also are disclosed that include one or more of the PYY analogs described herein in a pharmaceutically acceptable carrier. Methods of making and using the PYY analogs also are disclosed, especially for treating obesity and obesity-related diseases and disorders such as type II diabetes mellitus.
Claims12
A Peptide Tyrosine-Tyrosine (PYY) analog comprising an amino acid sequence of:
- (Formula I)
- PKPEX7PX9X10DASPEEX17X18RYYX22X23LRHYLNX30LTRQRY,
- wherein X7is any amino acid with a functional group available for conjugation and the functional group is conjugated to a C16-C22 fatty acid,
- wherein X9 is E or G,
- wherein X10 is E or K,
- wherein X17is L or W,
- wherein X18 is N or Q,
- wherein X22 is A or I,
- wherein X23 is E, D or S,
- wherein X30 is E or W (SEQ ID NO:3), and
- wherein a C-terminal amino acid is optionally amidated.
Dependencies are inferred from the claim text.