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US 12,269,821 B2Granted
Discovery of novel first in class nature-inspired compounds targeting the mitochondrial function and pharmaceutical composition thereof
AssigneeUniveristy of Sharjah
InventorsTaleb H. Altel, Vunnam Srinivasulu, Saleh Ibrahim, Paul Schilf
Life of this patent
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Abstract
The present invention relates to novel antitumor agents and pharmaceutically acceptable salts thereof, processes and intermediates for the manufacture of these novel constrained cyclic frameworks of general formula I and II, and medicaments containing such compounds.
Claims12
A novel compound of the formula I
- wherein,
- denotes a phenyl ring which may be unsubstituted or substituted with 1, 2, 3 or 4 substituents independently selected from a halogen atom, CN, R3, OR3, SR3, N(R3)2, C(O)R3, C(O)OR3, NR3C(O)R3, C(O)NR3, SO2R3, NR3SO2R3, or SO2N(R3)2;
- U
- denotes —CH2 or —O;
- R1
- denotes halogen atom, R3, OR3, SR3, N(R3)2, NR3C(O)R3, C(O)NR3, SO2R3, NR3SO2R3, or SO2N(R3)2;
- and
- R2
- denotes hydrogen, halogen atom, CN, R3, OR3, SR3, N(R3)2, C(O)R3, C(O)OR3, NR3C(O)R3, C(O)NR3, SO2R3, NR3SO2R3, SO2N(R3)2, CH2C(O)R3, CH2C(O)OR3, CH2NR3C(O)R3, CH2C(O)NR3, CH2SO2R3, CH2NR3SO2R3, or CH2SO2N(R3)2;
- and
- R3 is independently hydrogen or an optionally substituted group selected from a C1-6 aliphatic group, a monocyclic 3-8 membered saturated, partially unsaturated, or aryl ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a bicyclic 8-10 membered saturated, partially unsaturated, or aryl ring having 0-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
- or a pharmaceutically acceptable salt thereof.
9 more elements
A novel compound of the formula V
- wherein
- denotes a phenyl ring which may be unsubstituted or substituted with 1, 2, 3 or 4 substituents independently selected from a halogen atom, CN, R3, OR3, SR3, N(R3)2, C(O)R3, C(O)OR3, NR3C(O)R3, C(O)NR3, SO2R3, NR3SO2R3, or SO2N(R3)2;
- U
- denotes —CH2 or —O;
- R1
- denotes halogen atom, R3, OR3, SR3, N(R3)2, NR3C(O)R3, C(O)NR3, SO2R3, NR3SO2R3, or SO2N(R3)2;
- R2
- denotes hydrogen, halogen atom, CN, R3, OR3, SR3, N(R3)2, C(O)R3, C(O)OR3, NR3C(O)R3, C(O)NR3, SO2R3, NR3SO2R3, SO2N(R3)2, CH2C(O)R3, CH2C(O)OR3, CH2NR3C(O)R3, CH2C(O)NR3, CH2SO2R3, CH2NR3SO2R3, or CH2SO2N(R3)2;
- and
- R3 is independently hydrogen or an optionally substituted group selected from a C1-6 aliphatic group, a monocyclic 3-8 membered saturated, partially unsaturated, or aryl ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a bicyclic 8-10 membered saturated, partially unsaturated, or aryl ring having 0-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
- or a pharmaceutically acceptable salt thereof.
8 more elements
Dependencies are inferred from the claim text.