Benzothiophene compound, preparation method therefor and use thereof

A compound of formula (I):

• wherein
• both X1 and X3 are —O—;
• X2 is C1-6 alkylene, wherein the C1-6 alkylene, is optionally substituted with one or more substituents independently selected from the group consisting of halogen, cyano, hydroxy, C1-6 alkyl and C1-6 alkoxy;
• L1 is —(C(R8)2)p—;
• L2 is —C(O)—;
• L3 is —(C(R9)2)q—;
• A1 is —C(O)—ORa;
• R1 and R4 are H;
• R2 and R3 are the same or different, and are each independently selected from the group consisting of H, halogen, cyano, —ORa, —SRa, —S(O)Ra, —S(O)2Ra, —NRaRb, —C(O)—NRaRb, —NRa—C(O)—Ra, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, 3-6 membered heterocyclyl, C6-10 aryl and 5-10 membered heteroaryl, wherein the C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, 3-6 membered heterocyclyl, C6-10 aryl and 5-10 membered heteroaryl are each optionally substituted with one or more substituents independently selected from the group consisting of halogen, C1-6 alkyl, C1-6 haloalkyl, cyano, hydroxy and C1-6 alkoxy;
• R5 is selected from the group consisting of H, C1-6 alkyl, C3-10 cycloalkyl and 3-10 membered heterocyclyl, wherein the C1-6 alkyl, C3-10 cycloalkyl and 3-10 membered heterocyclyl are each optionally substituted with one or more substituents independently selected from the group consisting of halogen, cyano, hydroxy, C1-6 alkyl, C3-10 cycloalkyl, 3-10 membered heterocyclyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, —NRaRb, —CO2Ra and —S(O)2Ra;
• R6 is ORa or —C(O)2R7;
• R7 is selected from the group consisting of H and C1-6 alkyl;
• R8 is each independently selected from the group consisting of H and C1-6 alkyl;
• R9 is each independently selected from the group consisting of H and C1-6 alkyl;
• Ra and Rb are each independently selected from the group consisting of H and C1-6 alkyl wherein the C1-6 alkyl is optionally substituted with one or more substituents independently selected from the group consisting of hydroxy, halogen and C1-6 alkyl;
• m and n are each independently selected from the group consisting of 0, 1, 2 and 3;
• and
• p and q are each independently selected from the group consisting of 1, 2, and 3,
• or a pharmaceutically acceptable salt, a stereoisomer, a tautomer, a polymorph, a solvate, an N-oxide, or an isotope-labeled compound thereof.