Devices, systems, and methods for delivering therapy to intestinal muscle

A method for delivering a stimulation signal to an intestinal muscle of a patient comprising:

• receiving electrocardiographic data of a heart from a cardiac sensor;
• receiving intestinal activity data from an intestinal sensor, wherein the intestinal activity data is data from a duodenum, a jejunum, or an ileum of the patient;
• determining a physiological state of the patient based on the electrocardiographic data;
• calculating an intestinal activity parameter from the intestinal activity data;
• adjusting stimulation signal based on the determined physiological state and the intestinal activity parameter, wherein one or more of an amplitude, a frequency, a pulse width, a burst interval, a duty cycle, and a stimulation duration of the stimulation signal is adjusted based on the intestinal activity parameter;
• and
• applying the adjusted stimulation signal to the intestinal muscle of the patient.

A system for delivering an electrical stimulus to a muscle of a small intestine of a patient comprising:

• a cardiac sensor;
• an intestinal sensor;
• an implantable signal delivery device configured to deliver a stimulation signal to the muscle;
• an implantable pulse generator comprising a microcontroller configured to:
• receive cardiac data from the cardiac sensor and calculate a heart rate parameter from the cardiac data;
• receive intestinal activity data from the intestinal sensor and calculate an intestinal activity parameter from the intestinal activity data;
• determine a physiological state of the patient based on the heart rate parameter;
• adjust a stimulation signal based on the determined physiological state and the intestinal activity parameter, wherein one or more of an amplitude, a frequency, a pulse width, a burst interval, a duty cycle, and a stimulation duration of the stimulation signal is adjusted based on the intestinal activity parameter;
• and
• instruct the implantable signal delivery device to deliver the adjusted stimulation signal.

An implantable pulse generator comprising:

• a non-transitory computer readable memory comprising instructions to:
• calculate a heart rate parameter from cardiac data received from a cardiac sensor;
• calculate an intestinal activity parameter from intestinal activity data received from an intestinal sensor;
• determine a physiological state of a patient based on the heart rate parameter;
• and
• adjust a stimulation signal based on the determined physiological state and the intestinal activity parameter, wherein one or more of an amplitude, a frequency, a pulse width, a burst interval, a duty cycle, and a stimulation duration of the stimulation signal is adjusted based on the intestinal activity parameter;
• and
• a microcontroller configured to execute the instructions.