Platform drug delivery system utilizing crystal engineering and theanine dissolution
AssigneeTheaprin Pharmaceuticals Inc.
InventorsHarry G. Brittain, Philip V. Felice
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Abstract
A platform drug delivery system and a method of improving the delivery of low solubility pharmaceuticals utilizing crystal engineering and Theanine dissolution resulting in enhanced bioactivity, dissolution rate, and solid state stability.
Claims4
A cocrystal composition comprising L-theanine;
- and
- R-Ibuprofen,
- wherein the cocrystal is characterized by an X-ray powder diffraction pattern with peaks (2θ) at 13.1±0.2 degrees 2θ, 17.5±0.2 degrees 2θ, 21.9±0.2 degrees 2θ, and 26.3±0.2 degrees 2θ.
A method of treating soft tissue injury in a subject in need thereof, comprising administering to the subject an effective amount of a water-soluble composition comprising:
- a cocrystal containing R-Ibuprofen and L-theanine;
- wherein the cocrystal is characterized by an X-ray powder diffraction pattern with peaks (2θ) at 13.1±0.2 degrees 2θ, 17.5±0.2 degrees 2θ, 21.9±0.2 degrees 2θ, and 26.3±0.2 degrees 2θ.
A method of treating inflammatory pain in a subject in need thereof, comprising administering to the subject an effective amount of a water-soluble composition comprising:
- a cocrystal containing R-Ibuprofen and L-theanine;
- wherein the cocrystal is characterized by an X-ray powder diffraction pattern with peaks (2θ) at 13.1±0.2 degrees 2θ, 17.5±0.2 degrees 2θ, 21.9±0.2 degrees 2θ, and 26.3±0.2 degrees 2θ.
A method of treating acute renal colic pain, acute pericarditis pain, dental pain, or ligament injuries pain in a subject in need thereof, comprising administering to the subject an effective amount of a water-soluble composition comprising:
- a cocrystal containing R-Ibuprofen and L-theanine;
- wherein the cocrystal is characterized by an X-ray powder diffraction pattern with peaks (2θ) at 13.1±0.2 degrees 2θ, 17.5±0.2 degrees 2θ, 21.9±0.2 degrees 2θ, and 26.3±0.2 degrees 2θ.
Dependencies are inferred from the claim text.