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US 12,268,780 B1Granted
Transparent water nanolipid fluid (DNLF) dispersions and method of preparation using a twin screw extruder
OwnerEric Morrisoninventor
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Abstract
The present invention provides a method of preparing a lipid nanoparticle dispersion using a twin screw extruder. The inventive DNLF fluids are isotropic fluids which include greater than 25% lipophilic content in the form of lipidic nanoparticles dispersed in a continuous aqueous matrix with turbidity less than 375 nephelometric turbidity units (NTU).
Claims23
A lipid nanoparticle dispersion comprising:
- from 11.1 to 19.8 wt. % of one or more polyethoxylated high hydrophile-lipophile-balance (HLB) surfactants selected from the group consisting of laureth-23, ceteareth-20, ceteareth-30, steareth-40, PEG32 stearate, PEG75 stearate, PEG100 stearate, PEG15 hydroxy stearate, PEG40 hydrogenated castor oil, polysorbate 20, polysorbate 80, and combinations thereof;
- from 3.3 to about 10.1 wt. % of one or more low hydrophile-lipophile-balance (HLB) surfactants selected from the group consisting of cetyl alcohol, glyceryl oleate, glyceryl stearate, glyceryl monolinoleate, oleic acid, stearic acid, sorbitan oleate, soy lecithin, and combinations thereof;
- one or more water immiscible oils selected from the group consisting of medium chain triglyceride oil, coconut oil, isopropyl palmitate, isopropyl myristate, methyl decanoate, ethyl myristate, ethyl oleate, mineral oil, orange essential oil, cyclopentasiloxane, poly(dimethyl siloxane), hexadecane, propylene glycol dicaprylate, isododecane, isoeicosane, isohexadecane, soy biodiesel, jojoba oil, cocoyl caprylocaprate, C10-C13 alkane, squalane, sunflower seed oil, and combinations thereof;
- and
- water,
- wherein the lipid nanoparticle dispersion has a lipophilic concentration greater than about 25%, a volume average particle size less than about 100 nm, and a turbidity less than 375 nephelometric turbidity units (NTU) at room temperature.
3 more elements
A lipid nanoparticle dispersion comprising:
- from about 10 to about 15 wt. % of one or more polyethoxylated high hydrophile-lipophile-balance (HLB) surfactants selected from the group consisting of laureth-23, ceteareth-20, ceteareth-30, steareth-40, PEG32 stearate, PEG75 stearate, PEG100 stearate, PEG15 hydroxy stearate, PEG40 hydrogenated castor oil, polysorbate 20, polysorbate 80, and combinations thereof;
- from about 8 to about 12 wt. % of one or more low hydrophile-lipophile-balance (HLB) surfactants selected from the group consisting of cetyl alcohol, glyceryl oleate, glyceryl stearate, glyceryl monolinoleate, oleic acid, stearic acid, sorbitan oleate, soy lecithin, and combinations thereof;
- from about 20 to about 40 wt. % of one or more water immiscible oils selected from the group consisting of medium chain triglyceride oil, coconut oil, isopropyl palmitate, isopropyl myristate, methyl decanoate, ethyl myristate, ethyl oleate, mineral oil, orange essential oil, cyclopentasiloxane, poly(dimethyl siloxane), hexadecane, propylene glycol dicaprylate, isododecane, isoeicosane, isohexadecane, soy biodiesel, jojoba oil, cocoyl caprylocaprate, C10-C13 alkane, squalane, sunflower seed oil, and combinations thereof;
- and
- from about 35 to about 60 wt. % water,
- wherein the lipid nanoparticle dispersion has:
- a lipophilic concentration greater than about 25%;
- a volume average particle size less than about 100 nm;
- and
- a turbidity less than 375 nephelometric turbidity units (NTU).
7 more elements
Dependencies are inferred from the claim text.