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US 12,268,773 B2Granted
Shear-thinning therapeutic composition, and related methods
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsXiaochu Ding, Jin Gao, Yadong Wang
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Abstract
A shear-thinning therapeutic composition is provided along with methods of making and using the therapeutic composition.
Claims20
A shear-thinning therapeutic composition, comprising:
- silicate platelets;
- a gelling agent non-covalently linking the platelets to form a shear-thinning composition;
- and
- a therapeutic agent that binds non-covalently to the gelling agent and that is complexed non-covalently with the gelling agent,
- wherein the gelling agent is a sulfated or sulfamated polymer, a sulfated or sulfamated polysaccharide, a sulfated or sulfamated glycosaminoglycan, an anionic amino acid, or an anionic polypeptide.
2 more elements
A method of making a composition for delivery of a therapeutic agent, comprising:
- mixing a gelling agent with a therapeutic agent that is a binding partner of the gelling agent to produce a complex of the gelling agent and the therapeutic agent;
- and
- mixing the complex of the gelling agent and the therapeutic agent with silicate platelets to produce a shear-thinning hydrogel, wherein the gelling agent is a sulfated or sulfamated polymer, a sulfated or sulfamated polysaccharide, a sulfated or sulfamated glycosaminoglycan, an anionic amino acid, or an anionic polypeptide.
Dependencies are inferred from the claim text.