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US 12,268,760 B2Granted
Compositions of and methods of making ferritin-based imaging agents
AssigneeWashington University
InventorsKevin Bennett, Edwin Baldelomar
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Abstract
Among the various aspects of the present disclosure is the provision of methods and compositions for detecting recombinant cationic ferritin imaging agents. Also provided are transgenic microorganisms capable of synthesizing a recombinant ferritin imaging agent and methods of making the same. The imaging agents described herein can be used to effectively and noninvasively detect renal pathologies and are suitable for use in a number of imaging modalities.
Claims10
An imaging agent comprising:
- a recombinant ferritin fusion protein comprising at least one heavy chain subunit of ferritin and at least one light chain subunit of ferritin;
- and
- a magnetic nanoparticle core, wherein the magnetic nanoparticle core is bound within the recombinant ferritin fusion protein.
Dependencies are inferred from the claim text.