Peptidomimetics for the treatment of coronavirus and picorna virus infections

A compound of Formulas III or V:

• or a pharmaceutically acceptable salt thereof,
• wherein:
• R1 is optionally substituted aryl, 5-membered ring heteroaryl, aryloxy, heteroaryloxy, or heteroarylalkoxy,
• R3 is an optionally substituted arylalkyl, alkylaryl, heteroarylalkyl, or alkylheteroaryl, —CH2-(hydroxy) phenyl, and —CH2-(halo) phenyl,
• R4 is an optionally substituted C1-6 alkyl,
• R5 is CH═C(CN)C(O)NH2, —C(O)CF3, —CH(OH)CF3, —C(OH)SO3− (and an associated cation), or an optionally-substituted epoxide ring,
• R2, R2′, R10 and R10′ are, independently, hydrogen, CF3, C1-6 alkyl, C1-6 haloalkyl, or C2-6 alkenyl,
• X is, independently, a bond or NH,
• n and p are, independently, 0, 1, 2, or 3;
• m is 2,
• p is 0;
• R6 and R6′ are, independently, hydrogen, halogen, CF3, hydroxy, N(R′)S(O)2R′, S(O)2R′, S(O)2N(R′)2, C1-6 alkoxy, C2-6 alkenyl, cyano, C2-6 alkynyl, C3-6 alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, C1-6 alkyl, arylalkoxycarbonyl, carboxy, C1-6 haloalkyl, heterocyclylalkyl, or C1-6 hydroxyalkyl;
• or R6 and R6′, together with the carbon to which they are attached, form a carbonyl,
• each R′ is, independently, H, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, aryl, heteroaryl, alkylaryl, or arylalkyl,
• the R′ groups can optionally be substituted with one or more substituents, which substituents are, independently, halo, C1-6 haloalkyl, C1-6 hydroxyalkyl, hydroxyl, carboxyl, acyl, aryl, acyloxy, amino, amido, carboxyl derivatives, alkylamino, dialkylamino, arylamino, alkoxy, alkoxyalkyl, aryloxy, nitro, cyano, sulfonic acid, thiol, imine, sulfonyl, sulfanyl, sulfinyl, sulfamonyl, ester, carboxylic acid, amide, phosphonyl, phosphinyl, phosphoryl, phosphine, thioester, thioether, acid halide, anhydride, oxime, hydrozine, carbamate, phosphonic acid, or phosphonate;
• two R′ residing on the same carbon or nitrogen atom can come together to form a C3-6 ring optionally containing a N, O, or S heteroatom;
• R6 and R6′ can come together to form an optionally substituted double bond or a C3-6 ring optionally containing a N, O, or S heteroatom;
• R7 and R7′ are, independently, hydrogen, CF3, N(R′) S(O)2R′, S(O)2R′, S(O)2N(R′)2, C1-6 alkoxy, C2-6 alkenyl, cyano, C2-6 alkynyl, C3-6 alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, C1-6 alkyl, arylalkoxycarbonyl, carboxy, C1-6 haloalkyl, heterocyclylalkyl, or C1-6 hydroxyalkyl;
• and
• R7 and R7′ can come together to form an optionally substituted double bond or a C3-6 ring optionally containing a N, O, or S heteroatom;
• wherein, with respect to Formula V, m is 1.