Compositions and uses of locally-applied antimicrobial synthetic cationic polypeptide(s) with enhanced performance and safety

An antimicrobial pharmaceutical composition, comprising:

• an aqueous carrier;
• and
• at least one antimicrobial synthetic cationic polypeptide(s) dispersed in the aqueous carrier at a concentration in the range of about 0.01% to about 5%, by weight based on total weight of the antimicrobial pharmaceutical composition;
• wherein:
• the at least one antimicrobial synthetic cationic polypeptide(s) comprises at least 40 amino acid units;
• the at least one antimicrobial synthetic cationic polypeptide(s) comprises at least one cationic segment with a plurality of positively charged amino acid units at neutral pH and a hydrophobic segment with a plurality of hydrophobic amino acid units;
• the ratio of the length of the cationic segment to the length of the hydrophobic segment is between about 1.5 and about 6;
• the at least one antimicrobial synthetic cationic polypeptide(s) at a concentration of 2 wt % in deionized water has a viscosity at 37° C. of 2 centistokes (cSt) or greater;
• and
• the aqueous carrier, containing the antimicrobial synthetic cationic polypeptide(s) at 2 wt %, has a viscosity at 37° C. that is greater than that of the aqueous carrier containing albumin at 2 wt % in place of the at least one antimicrobial synthetic cationic polypeptide(s).