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US 12,268,718 B2Granted
Control of cellular redox levels
OwnerElizabeth McKennainventor
Life of this patent
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Abstract
Disclosed herein are compositions and methods for regulating redox status and/or reducing oxidative stress in a subject, the methods and compositions comprising TLR agonists comprising bacterial lysates and/or lysate fractions. Also disclosed are compositions and methods comprising bacterial lysates and/or lysate fractions formulated or administered in combination with one or more other therapeutic or pharmaceutical agents.
Claims10
A method of regulating redox status in a subject, the method comprising administering a therapeutically effective amount of a composition to a subject in need thereof, the composition comprising:
- (a) at least one lysate of an inactivated Gram-positive bacterium comprising the entire cellular contents of the bacterium cell, wherein the lysate of the Gram-positive bacterium comprises a toll-like receptor (TLR) agonist that regulates redox status in the subject, wherein the TLR agonist activates two or more TLRs, wherein the two or more TLRs comprise TLR2 and TLR4, and wherein the Gram-positive bacterium is inactivated by a heat treatment of the Gram-positive bacterium and by a lysozyme treatment of the Gram-positive bacterium;
- (b) an optional promoter for enhancing absorption of the composition;
- and
- (c) an optional carrier for increasing a volume of the composition,
- wherein redox status regulation is assessed by measuring changes in isoprostane concentration in a subject and wherein administration of an effective amount of the composition to the subject measurably reduces oxidative stress levels and decreases isoprostane concentration in the subject.
2 more elements
Dependencies are inferred from the claim text.