Method of treating severe forms of pulmonary hypertension
AssigneeReversPAH LLC
InventorsNorbert F. Voelkel, Charles Magolske
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Abstract
A method of treating severe forms of PH, including PAH, in a patient is provided. The method includes administering at least one copper chelator comprising a tetrathiomolybdate (TTM) salt. The method may further include administering at least one active agent that enhances treatment such as methotrexate, inhibitors of the 5-lipoxygenase enzyme (5-LO), rituximab, baicalin, inhibitors of immune checkpoints CTLA-4, PD-1 and PDL-1, bufalin, quercetin, curcumin, integrins, inhibitors of NF-kappaB, and focal adhesion kinase inhibitors. Also provided is a composition including the TTM salt and the at least one active agent.
Claims13
A method of treating pulmonary arterial hypertension (PAH) in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of a pharmaceutical composition comprising:
- a copper chelator comprising a tetrathiomolybdate salt;
- diethylcarbamazine (DEC);
- and a pharmaceutically acceptable carrier.
A pharmaceutical composition comprising:
- a copper chelator comprising a tetrathiomolybdate salt;
- diethylcarbamazine (DEC);
- and
- a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.