High resolution depth-encoding pet detector with prismatoid light guide array

A particle detector, comprising:

• a scintillator array comprising a plurality of scintillator crystals;
• a plurality of detectors provided on a first end of the scintillator array, where there are four scintillator crystals per detector;
• a plurality of prismatoids provided on a second end of the scintillator array, where the prismatoids are offset with the detectors such that at least two prismatoids overlap the same detector and each prismatoid is on the second end of scintillator crystals optically coupled with at least two different detectors to redirect particles between the second ends of scintillator crystals optically coupled with the at least two different detectors;
• and
• at least one processor in operative communication with the plurality of detectors,
• wherein the at least one processor comprises a plurality of supervised machine learning algorithms configured to perform three dimensional (3D) gamma ray localization of at least one interaction site within at least one scintillator crystal of the plurality of scintillator crystals.