Device and method for characterising the roughness profile of a tissue sample

A device for characterizing a rough profile of a tissue sample, comprising:

• a laser source that illuminates the surface of the tissue sample with a continuous wave laser beam;
• a photodetector that receives the light scattered in reflection by the surface of the tissue sample illuminated by the laser beam;
• and
• a structure that comprises:
• a guide arranged in front of the laser source perpendicular to the emitted laser beam;
• a frame movable along the guide, the ground glass plate and the half wave blade being coupled to said frame:
• a translation motor configured to move the frame along the guide to selectively place the ground glass plate, the half wave blade in the path of the laser beam, or neither the ground glass plate nor the half wave blade are positioned in the path of the laser beam;
• and
• a rotation motor coupled to the ground glass plate and the half wave blade to rotate respectively the ground glass plate and the half wave blade when the ground glass plate and the half wave blade are in front of the laser source, wherein the structure is configured to alternate between:
• a first position wherein a rotating ground glass plate is disposed within a path of the laser beam towards the surface;
• a second position wherein a rotating half wave blade is disposed within the path of the laser beam towards the surface;
• and
• a third position wherein neither the ground glass plate nor the half wave blade are arranged within the path of the laser beam towards the surface, or the half wave blade is in a fixed non-rotating position.