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US 12,264,348 B2Granted
Microorganism with knock-in at acetolactate decarboxylase gene locus
AssigneeLanzaTech, Inc.
InventorChing Leang
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Abstract
Provided herein is a genetically engineered microorganism comprising knock-in of DNA at an acetolactate decarboxylase gene locus. Replacement of the acetolactate decarboxylase gene with DNA encoding one or more native or nonnative enzymes confers certain advantages, including fermentation stability and increased production of native and nonnative products from gaseous substrates.
Claims21
A genetically engineered C1-fixing microorganism comprising knock-in of DNA at an acetolactate decarboxylase gene locus, wherein the microorganism comprises oscillations in metabolite production and gas consumption.
Dependencies are inferred from the claim text.