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US 12,264,347 B2Granted
Repair of UV-induced DNA lesions
OwnerJeroen Hofenkinventor
Life of this patent
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Abstract
A composition comprising a recombinant enzyme that comprises a fusion of: a cyclobutane pyrimidine dimer photolyase corresponding to an amino acid encoding sequence having at least 85% sequence identity to SEQ ID NO 1, a pyrimidine(6-4)pyrimidone photolyase corresponding to an amino acid encoding sequence having at least 85% sequence identity to SEQ ID NO 2, and a skin penetrating peptide.
Claims15
A composition comprising a recombinant enzyme that comprises a fusion of a cyclobutane pyrimidine dimer photolyase corresponding to an amino acid encoding sequence of SEQ ID NO 1,
- a pyrimidine(6-4)pyrimidone photolyase corresponding to an amino acid encoding sequence of SEQ ID NO 2, and
- a skin penetrating peptide.
A nucleic acid molecule comprising a first fragment corresponding to SEQ ID NO:
- 1, coding for cyclobutane pyrimidine dimer photolyase, a second fragment corresponding to SEQ ID NO:
- 2, coding for a pyrimidine(6-4)pyrimidone photolyase and a third fragment that encodes a skin penetrating peptide.
Dependencies are inferred from the claim text.