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US 12,264,135 B2Granted
Synthesis of 1,4-diazaspiro[5.5]undecan-3-one
AssigneePharmacosmos Holding A/S
InventorsStephen E. Schneider, Hannah White, Thomas Fessard, Sagar Beldar
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Abstract
This invention provides a process for preparing 1,4-diazaspiro[5.5]undecan-3-one and analogues thereof that are useful in the preparation of pharmaceutical compound, including for the treatment of disorders involving abnormal cellular proliferation. Chemical intermediates in the process are also provided.
Claims18
A process to prepare a spirocyclic compound comprising:
- a. reducing a compound of Formula III with a reducing agent;
- b. cyclizing the compound of step (a);
- wherein Formula III is:
- wherein the spirocyclic compound is of Formula:
- wherein
- y is 0;
- n is 0 or 1;
- R1 is hydrogen;
- R2 is hydrogen, substituted heteroaryl, or
- R3 is hydrogen;
- R4 is NR8R9 or OR10;
- R8 and R9 are independently selected from the group consisting of hydrogen, alkyl, aryl, and -alkyl-aryl;
- R10 is alkyl, aryl, or -alkyl-aryl;
- R12 is alkyl, aryl, or -alkyl-aryl;
- and
- R13 is —S-alkyl or Cl.
13 more elements
Dependencies are inferred from the claim text.