Medicament preparation devices, methods, and systems

A fluid circuit, comprising:

• a valve network having a water line, a drain line, a concentrate line, and a product fluid line;
• an empty mixing container;
• a prefilled concentrate container;
• the water line, the product fluid line, and the drain line being connected to the empty mixing container both directly and also through a pumping tube segment via respective mixing container inlet and outlet lines;
• the mixing container inlet line having a check valve and the mixing container outlet line being configured mate with a control valve;
• and
• the check valve having a predefined cracking pressure.

A method for mixing a batch of medicament, comprising:

• providing a system that includes
• a pump actuator and control valve actuators controlled by a controller;
• a fluid circuit fluidly connected to the pump actuator and valve actuators;
• the fluid circuit including a concentrate container filled with a concentrate or a concentrate connector for connection to the concentrate container;
• the fluid circuit being connected to a mixing container by an inlet line and an outlet line of the mixing container at ends of a pumping tube segment that engages the pump actuator to form a peristaltic pump;
• fluid circuit having a drain line connectable to a conductivity sensor;
• a water pump connected to be controlled by the controller, the water pump being configured to pump purified water from a purified water source;
• using the controller, controlling the valve actuators to open fluid channels from the concentrate container or the concentrate connector and to open channels from the purified water source to connect a junction of the fluid circuit to the concentrate and purified water source;
• using the controller, controlling the pump actuator and the water pump to flow water and concentrate into said junction, the junction being connected to said mixing container inlet line, such that water and concentrate flow concurrently into the mixing container;
• using the controller, controlling the peristaltic pump and the water pump to flow concentrate in proportion such that a mixture of the concentrate and the purified water in the mixing container requires additional dilution to form a ready-to-use medicament;
• using the controller, collecting a sample of contents of the mixing container from the drain line and measuring a conductivity of the sample with the conductivity sensor;
• and
• using the controller, calculating an additional quantity of water to add to the mixing container responsively to the conductivity measured.