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AssigneeElektrofi, Inc.
InventorsChase Spenser Coffman, Lyndon Fitzgerald Charles, Jr., Paul Brown, Daniel Benjamin Dadon, Lisa Liu, Cory Robinson, Dale Arlington Thomas, III
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The invention provides methods for the preparation of particles including one or more agents, e.g., therapeutic or diagnostic agents. The particles can be formed by creating droplets of a first liquid, e.g., including an agent, and removing the first liquid, e.g., through its dispersal in a second liquid and/or evaporation, to solidify the droplets. Advantageously, the process of forming the particles does not significantly alter the structure or activity of the agents and may enhance the stability of the agents. For example, the particles may be stored for long periods of time without significant loss of activity, and in some embodiments, without the need for refrigeration. These particles may be used to generate stabilized pharmaceutical compositions for storage or other logistical purposes, pharmaceutical suspensions, pharmaceutical powder formulations (e.g., inhalable powders, injectable powders), creams or other topical pastes, nutraceuticals, or cosmetics.
A composition comprising particles, wherein a plurality of particles are round particles having a sphericity greater than 0.9, wherein the plurality of particles comprise an excipient and a therapeutic agent, wherein a mass loading of the therapeutic agent in the plurality of particles is between 50% and 100%, wherein the therapeutic agent is a protein, peptide, or nucleic acid, and wherein the excipient is a salt, an amino acid, a surfactant, or a carbohydrate.
Dependencies are inferred from the claim text.