Manufacturing of pharmaceutical compositions

An apparatus for the continuous manufacture of a liquid pharmaceutical composition, comprising:

• at least two dedicated dispensers configured to contain a supply of a therapeutic agent and a liquid vehicle, respectively, wherein each dispenser comprises a release actuator, wherein the release actuator of the dispenser configured to contain the liquid vehicle is configured to trigger dispensing of the liquid vehicle at a predetermined, time-steady rate and the release actuator of the dispenser configured to contain the therapeutic agent is configured to trigger dispensing of the therapeutic agent at a predetermined, time-steady rate, wherein each of the rate at which the therapeutic agent is dispensed and the rate at which the liquid vehicle is dispensed is independently adjustable;
• a mixer downstream of the dispensers, wherein the mixer is fluidly connected with the dispensers and comprises a mixing chamber having proximal and distal ends, a feeding inlet at a proximal end of the mixing chamber and a discharging outlet at a distal, opposite end of the mixing chamber, wherein the chamber is configured to receive the therapeutic agent and the liquid vehicle through said inlet, wherein the mixer is configured to obtain a liquid composition having a concentration of the therapeutic agent;
• a holder downstream of the mixer, wherein the holder is fluidly connected with the discharging outlet of the mixer and comprises an inlet and an outlet and is configured to hold the liquid composition for a residence time that is at least sufficient to normalize the concentration of the therapeutic agent, and
• conveyors arranged to fluidly connect the dispensers with the feeding inlet of the mixer, and to fluidly connect the discharging outlet of the mixer with the inlet of the holder, wherein the conveyors connecting the dispenser configured to contain the therapeutic agent and the mixer comprise an in-line microwave weigher including a processor,
• wherein the in-line microwave weigher including the processor is configured to (i) perform in-line taking of microwave spectra of the therapeutic agent suitable to measure mass and moisture content of the therapeutic agent, (ii) output data representing the measured mass and moisture content, (iii) process the data to generate a corresponding signal, and (iv) provide the signal to the dispensers to permit dynamic adjustment of the rate at which the release actuators of one or both of the therapeutic agent and the liquid vehicle dispense the respective materials from the dispensers.