Vaccine for use in the prophylaxis and/or treatment of a disease
AssigneeInprother Aps
InventorsPeter Holst, Christian Thirion, Lasse Neukirch
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Abstract
The present invention relates to an adenoviral vector capable of encoding a virus-like particle (VLP), said VLP displaying an inactive immune-suppressive domain (ISD). The vaccine of the invention shows an improved immune response from either of both of the response pathways initiated by CD4 T cells or CD8 T cells.
Claims13
A virus-like particle (VLP), wherein the VLP is encoded by a nucleic acid molecule encoding a Gag protein and an ERV envelope (Env) protein or an immunogenic part thereof, wherein the native genomic structure connecting Gag and Env has been replaced by an operative linker, wherein the ERV is HERV-K.
Dependencies are inferred from the claim text.