Combinations of monoamine oxidase inhibitors and serotonin receptor agonists and their therapeutic use
AssigneeRemedi Co., Ltd.
InventorsTom Spector, Jeremy Ford, Thomas A. Krenitsky
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Abstract
Disclosed are methods of treating a subject having a disease or disorder by administering a monoamine oxidase inhibitor in combination with a serotonin receptor agonist, which in some embodiments is a deuterated serotonin receptor agonist. In some aspects, the disclosure further relates to pharmaceutical compositions and kits comprising a monoamine oxidase inhibitor and a serotonin receptor agonist. In some embodiments, the monoamine oxidase inhibitor is a MAO-A-selective inhibitor such as CX157, and the serotonin receptor agonist is a serotonin 2A receptor agonist such as N,N-dimethyltryptamine (DMT), or deuterated DMT.
Claims19
A pharmaceutical composition or kit of parts, useful to treat a mental health disorder in a human, comprising therapeutically effective amounts of:
- a) a compound having the formula:
- (CX157), or a pharmaceutically acceptable salt thereof;
- and
- b) N,N-dimethyltryptamine (DMT), or a pharmaceutically acceptable salt thereof;
- wherein the DMT is formulated for oral administration.
Dependencies are inferred from the claim text.