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US 12,260,976 B2Granted
Magnetic bead and magnetic bead dispersion
AssigneeSeiko Epson Corporation
InventorsYasunari Ikeda, Michio Nakamori, Hirofumi Hokari
Life of this patent
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Abstract
A magnetic bead contains: a magnetic metal powder; and a coating layer with which a particle surface of the magnetic metal powder is coated. When the magnetic bead is left to stand in a state of a dispersion obtained by dispersing the magnetic bead in water, a time until an initial absorbance of the dispersion attenuates to 80% of an absorbance when the standing is started is 90 seconds or longer.
Claims6
A magnetic bead comprising:
- a magnetic metal powder;
- and
- a coating layer with which a particle surface of the magnetic metal powder is coated, the coating layer being a composite containing silicon and one or more selected from the group consisting of Al, Ti, V, Nb, Cr, Sn, and Zr,
- wherein the coating layer includes a functional group configured to enhance binding of a biological substance to the magnetic bead, the functional group being selected from the group consisting of an OH group, an epoxy group, a trimethylsilyl group, and a NHS group,
- an average particle size D50 of the magnetic bead is 0.5 μm or more and 50 μm or less,
- a ratio D90/D50 of a 90% particle size D90 in a particle size distribution of the magnetic bead to the average particle size D50 is 2.00 or less, and
- when the magnetic bead is left to stand in a state of a dispersion obtained by dispersing the magnetic bead in water, a time until an initial absorbance of the dispersion attenuates to 80% of an absorbance when the standing is started is 90 seconds or longer.
4 more elements
Dependencies are inferred from the claim text.