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US 12,259,395 B2Granted
Catabodies and methods of use thereof
AssigneeAb Studio Inc.
InventorYue Liu
Life of this patent
Estimating the term…
Abstract
The present application provides methods, compositions and kits for determining SHD catabody levels in a biological sample, and for treating or preventing a protein aggregation disease (PAD) in an individual. Also provided are catabodies specifically recognizing amyloid beta (Aβ) peptides and methods of use thereof.
Claims5
A method of treating Alzheimer's disease in an individual, comprising administering to the individual an effective amount of an anti-Aβ catabody, wherein the anti-Aβ catabody comprises:
- (i) an immunoglobulin heavy chain variable domain (VH) comprising the amino acid sequence of SEQ ID NO:
- 4, and an immunoglobulin light chain variable domain (VL) comprising the amino acid sequence of SEQ ID NO:
- 5, (ii) a VH comprising the amino acid sequence of SEQ ID NO:
- 6, and a VL comprising the amino acid sequence of SEQ ID NO:
- 7;
- (iii) a VH comprising the amino acid sequence of SEQ ID NO:
- 6, and a VL comprising the amino acid sequence of SEQ ID NO:
- 8;
- (iv) a VH comprising the amino acid sequence of SEQ ID NO:
- 19, and a VL comprising the amino acid sequence of SEQ ID NO:
- 21;
- (v) a VH comprising the amino acid sequence of SEQ ID NO:
- 20, and a VL comprising the amino acid sequence of SEQ ID NO:
- 21;
- (vi) a VH comprising the amino acid sequence of SEQ ID NO:
- 19, and a VL comprising the amino acid sequence of SEQ ID NO:
- 22;
- or (vii) a VH comprising the amino acid sequence of SEQ ID NO:
- 20, and a VL comprising the amino acid sequence of SEQ ID NO:
- 22.
17 more elements
Dependencies are inferred from the claim text.