System, method, apparatus and diagnostic test for plasmodium vivax
AssigneeThe Walter and Eliza Hall Institute of Medical Research
InventorsIvo Mueller, Takafumi Tsuboi, Michael White, Rhea Longley
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Abstract
A system, method, apparatus and diagnostic test for Plasmodium vivax, to determine a likelihood of a specific timing of infection by P. vivax in a subject, and hence identify individuals with a high probability of being infected with otherwise undetectable liver-stage hypnozoites. The system, method, apparatus and diagnostic test relate to the identification of hypnozoites (“dormant” liver-stages), or at least of the likelihood of the subject being so infected. Optionally and preferably, the specific timing relates to recent infections, for example within the last 9 months.
Claims21
A diagnostic test for Plasmodium vivax, to determine a likelihood of a specific timing of infection by P. vivax in a subject by determining a level of antibodies to a plurality of antigens in a sample from the subject, wherein the level is measured of antibody to protein PVX_084720 (SEQ ID NO:35) and of at least one antibody to protein selected from at least one protein selected from the group consisting of PVX_099980 (L01) (SEQ ID NO:1), PVX_112670 (SEQ ID NO:
- 23), PVX_087885 (SEQ ID NO:45), PVX_082650 (SEQ ID NO:59), PVX_088860 (SEQ ID NO:
- 5), PVX_112680 SEQ ID NO:11), PVX_112675 SEQ ID NO:21), PVX_092990 (SEQ ID NO:
- 39), PVX_091710 (SEQ ID NO:43), PVX_117385 SEQ ID NO:49), PVX_098915 (SEQ ID NO:
- 77), PVX_088820 (SEQ ID NO:79), PVX_117880 (SEQ ID NO:7), PVX_121897 (SEQ ID NO:
- 95), PVX_125728 (SEQ ID NO:97), PVX_001000 (SEQ ID NO:65), PVX_084340 SEQ ID NO:
- 75), PVX_090330 (SEQ ID NO:99), PVX_125738 (SEQ ID NO:103), PVX_096995 (SEQ ID NO:
- 3), PVX_097715 (SEQ ID NO:13), PVX_094830 (SEQ ID NO:19), PVX_101530 (SEQ ID NO:
- 9), PVX_090970 (SEQ ID NO:27), PVX_003770 (SEQ ID NO:37), PVX_112690 (SEQ ID NO:
- 41), PVX_003555 (SEQ ID NO:47), PVX_090265 (SEQ ID NO:53), PVX_099930 (SEQ ID NO:
- 73), PVX_123685 (SEQ ID NO:101), PVX_002550 (SEQ ID NO:25), PVX_082700 (SEQ ID NO:55), PVX_097680 (SEQ ID NO:63), PVX_097625 (SEQ ID NO:67), PVX_082670 (SEQ ID NO:41), PVX_082735 (SEQ ID NO:81), PVX_082645 (SEQ ID NO:83), PVX_097720 (SEQ ID NO:107), PVX_000930 (SEO ID NO:
- 109), PVX_088820 (SEQ ID NO:79), PVX_087885 (SEQ ID NO:45), PVX_087110 (SEQ ID NO:69), and RBP2b (P25) (PVX_094255) (SEQ ID NO:61), wherein the level of antibodies is measured at a plurality of time points and wherein a model of the decay of antibody titers over time is used to determine the time since last infection, wherein the level of antibody is correlated with the time since infection.
Dependencies are inferred from the claim text.