Integrated syringe
AssigneeUniversity of Central Florida Research Foundation, Inc.
InventorsBrian Kim, Geoffrey Mulberry
Life of this patent
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Abstract
Various embodiments relate to a syringe for separating nucleic acids from a blood sample and systems that include the syringe and a portable PCR device. The syringe may include a shell defining a central aperture extending through a longitudinal axis of the syringe, a plunger disposed within the central aperture of the shell, and a core rotatably disposed within the central aperture. The syringe may further include a needle fluidically connectable to the inlet of the shell. Various embodiments relate to a method for separating nucleic acids from a blood sample, the method comprising drawing the blood sample from a patient using the syringe according to any of the embodiments described herein.
Claims11
A syringe for separating nucleic acids from a blood sample, the syringe comprising:
- a shell defining a central aperture extending through a longitudinal axis of the syringe, the shell comprising
- an inlet,
- a follower extending into the central aperture,
- a first chamber defined within a thickness of the shell,
- a first chamber inlet fluidically connecting the first chamber to the central aperture of the shell, and
- a first chamber outlet fluidically connecting the first chamber to the central aperture of the shell,
- a plunger disposed within the central aperture of the shell, the plunger comprising
- a profiled portion disposable within the central aperture to engage the follower of the shell to cause a rotational displacement about the longitudinal axis when the plunger is displaced along the longitudinal axis;
- a core rotatably disposed within the central aperture, the core comprising
- a membrane disposed within the core,
- a first channel disposable to form a fluidic connection between the inlet of the shell and the first chamber inlet, and
- a second channel disposable to form a fluidic connection between the first chamber outlet and the membrane.
A system comprising a syringe and a portable PCR device adapted to receive nucleic acids from the syringe, the syringe comprising
- a shell defining a central aperture extending through a longitudinal axis of the syringe, the shell comprising
- an inlet,
- a follower extending into the central aperture,
- a first chamber defined within a thickness of the shell,
- a first chamber inlet fluidically connecting the first chamber to the central aperture of the shell, and
- a first chamber outlet fluidically connecting the first chamber to the central aperture of the shell,
- a plunger disposed within the central aperture of the shell, the plunger comprising
- a profiled portion disposable within the central aperture to engage the follower of the shell to cause a rotational displacement about the longitudinal axis when the plunger is displaced along the longitudinal axis;
- a core rotatably disposed within the central aperture, the core comprising
- a membrane disposed within the core,
- a first channel disposable to form a fluidic connection between the inlet of the shell and the first chamber inlet, and
- a second channel disposable to form a fluidic connection between the first chamber outlet and the membrane.
Dependencies are inferred from the claim text.