Environmentally compatible detergents for inactivation of lipid-enveloped viruses
AssigneeTakeda Pharmaceutical Company Limited
InventorsJean-Baptiste Farcet, Johanna Kindermann, Björn Tille, Thomas R. Kreil
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Abstract
The present invention relates to methods for inactivating a lipid-enveloped virus using environmentally compatible detergents, and to methods for preparing a biopharmaceutical drug using environmentally compatible detergents. The invention also provides environmentally compatible detergents.
Claims32
A compound which is the following compound:
- wherein m equals 1 and z is an integer selected from the following group:
- z=1 to 5.
A method for synthesizing a compound of the following general Formula (VIII),
- wherein
- R represents a hydrocarbon group having a linear chain of 2 to 12 carbon atoms and one or more methyl groups as substituents on said linear chain,
- m equals 1, and
- A represents a polyoxyethylene residue,
- wherein the method comprises the steps of
- A) Converting a phenol of the following general Formula (IX) wherein R is as defined above
- into an alcohol of the of the following general Formula (X) wherein R and m are as defined above
- and
- (B) converting the alcohol of the general Formula (X) into a polyoxyethylene ether of the general Formula (VIII) as defined above;
- wherein the compound of Formula (VIII) is the following compound:
- wherein m equals 1 and z is an integer selected from the following group:
- z=1 to 5.
A method for synthesizing a compound of the following general Formula (VIII),
- Wherein
- R represents a hydrocarbon group having a linear chain of 2 to 12 carbon atoms and one or more methyl groups as substituents on said linear chain,
- m equals 1, and
- A represents a polyoxyethylene residue,
- wherein the method comprises the steps of
- (1) reacting toluene so as to obtain a substituted toluene of the following general Formula (XI) wherein R is as defined above
- (2) converting the substituted toluene of the general Formula (XI) into a compound of the following general Formula (XII), wherein R and m are as defined above and X is selected from the group comprising a hydroxyl group, a bromine atom, an iodine atom and a chlorine atom
- and
- (3) converting the compound of the general Formula (XII) into a polyoxyethylene ether of the general Formula (VIII) as defined above;
- wherein the compound of Formula (VIII) is the following compound:
- wherein m equals 1 and z is an integer selected from the following group:
- z=1 to 5.
A method for synthesizing a compound of the following general Formula (VIIIa),
- wherein
- R represents a hydrocarbon group having a linear chain of 2 to 12 carbon atoms and one or more methyl groups as substituents on said linear chain, and
- A represents a polyoxyethylene residue,
- wherein the method comprises the steps of
- (I) converting benzyl alcohol into a compound of the following general Formula (XIII), wherein R is as defined above
- and
- (II) converting the compound of the general Formula (XIII) into a polyoxyethylene ether of the general Formula (VIIIa) as defined above;
- wherein the compound of Formula (VIIIa) is the following compound:
- wherein m equals 1 and z is an integer selected from the following group:
- z=1 to 5.
Dependencies are inferred from the claim text.