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US 12,258,454 B2Granted
Swellable and structurally homogenous hydrogels and methods of use thereof
AssigneeMassachusetts Institute of Technology
InventorsRuixuan Gao, Linyi Gao, Chih-Chieh Yu, Edward Stuart Boyden
Life of this patent
Estimating the term…
Abstract
The invention encompasses hydrogels, monomer precursors of the hydrogels, methods for the preparation thereof, and methods of use therefor. The linking of monomers can take place using non-radical, bioorthogonal reactions such as copper-free click-chemistry.
Claims16
A hydrogel that is the product of a non-radical polymerization reaction between a monomer of Formula (A5):
- and a monomer of Formula (B1):
- wherein:
- each n is an integer greater than or equal to 1;
- each p is an integer greater than or equal to 1;
- E is a moiety comprising a charged functional group;
- Z is a counter ion;
- X and Y1 are each crosslinkable moieties;
- and
- X and Y1 covalently crosslink to end-link the monomers.
6 more elements
A monomer of Formula (A5):
- wherein:
- each n is an integer greater than or equal to 1;
- Z is a counter ion;
- X is a crosslinkable moiety;
- and
- E is a moiety comprising a charged functional group.
3 more elements
A monomer of Formula (B1):
- wherein:
- Y1 is a crosslinkable moiety;
- and
- each p is an integer greater than or equal to 1.
1 more element
Dependencies are inferred from the claim text.