Anti-FXI/FXIa antibody and use thereof

An antibody or antigen-binding fragment thereof capable of specifically binding to FXI and/or FXIa, wherein the antibody or antigen-binding fragment thereof comprises:

• (a) a heavy chain variable region (VH) comprising a CDR-H1 comprising the amino acid sequence of SEQ ID NO:
• 3, a CDR-H2 comprising the amino acid sequence of SEQ ID NO:
• 4, and a CDR-H3 comprising the amino acid sequence of SEQ ID NO:
• 5;
• and
• a light chain variable region (VL) comprising a CDR-L1 comprising the amino acid sequence of SEQ ID NO:
• 6, a CDR-L2 comprising the amino acid sequence of SEQ ID NO:
• 7, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO:
• 8;
• wherein the six CDRs are defined by the IMGT numbering system;
• (b) a VH comprising a CDR-H1 comprising the amino acid sequence of SEQ ID NO:
• 33, a CDR-H2 comprising the amino acid sequence of SEQ ID NO:
• 34, and a CDR-H3 comprising the amino acid sequence of SEQ ID NO:
• 35;
• and
• a VL comprising a CDR-L1 comprising the amino acid sequence of SEQ ID NO:
• 36, a CDR-L2 comprising the amino acid sequence of SEQ ID NO:
• 37, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO:
• 38;
• wherein the six CDRs are defined by the IMGT numbering system;
• (c) a VH comprising a CDR-H1 comprising the amino acid sequence of SEQ ID NO:
• 9, a CDR-H2 comprising the amino acid sequence of any one of SEQ ID NOs:
• 45, 46, and 10, and a CDR-H3 comprising the amino acid sequence of SEQ ID NO:
• 11;
• and a VL comprising a CDR-L1 comprising the amino acid sequence of SEQ ID NO:
• 12, a CDR-L2 comprising the amino acid sequence of SEQ ID NO:
• 13, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO:
• 14;
• wherein the six CDRs are defined by the AbM numbering system;
• or
• (d) a VH comprising a CDR-H1 comprising the amino acid sequence of SEQ ID NO:
• 39, a CDR-H2 comprising the amino acid sequence of SEQ ID NO:
• 40 or 47, and a CDR-H3 comprising the amino acid sequence of SEQ ID NO:
• 41;
• and a VL comprising a CDR-L1 comprising the amino acid sequence of SEQ ID NO:
• 42, a CDR-L2 comprising the amino acid sequence of SEQ ID NO:
• 43, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO:
• 44;
• wherein the six CDRs are defined by the AbM numbering system.