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US 12,258,362 B2Granted
Processes for preparing phosphorodiamidate morpholino oligomers
AssigneeSarepta Therapeutics, Inc.
InventorsBaozhong Cai, Mitchell Martini, Ross Shimabuku, Katie Thomas
Life of this patent
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Abstract
Provided herein are processes for preparing an oligomer (e.g., a morpholino oligomer). The synthetic processes described herein may be advantageous to scaling up oligomersynthesis while maintaining overall yield and purity of a synthesized oligomer.
Claims5
A compound of Formula (A9):
- or a pharmaceutically acceptable salt thereof, wherein:
- n is an integer from 10 to 40;
- R1 is a support-medium;
- R3 is selected from the group consisting of hydrogen, trityl, monomethoxytrityl, dimethoxytrityl and trimethoxytrityl;
- and
- R4 is, independently at each occurrence, selected from the group consisting of:
3 more elements
Dependencies are inferred from the claim text.