Bicyclic CX3CR1 receptor agonists

A process of making a compound of structural formula (I)

• comprising reacting a compound of structural formula (II)
• with a compound of structural formula (III)
• wherein
• n is an integer between 1 and 4, forming a 6-10-membered cycloalkyl;
• A is chosen from phenyl and heteroaryl, optionally substituted with one or more C1-C3 alkyl substituents;
• R1 is hydrogen;
• R2 and R3 are independently chosen from hydrogen, phenyl, and C1-C6 alkyl;
• or R2 and R3 are joined together via a group Y, such that R2-Y-R3, together with the carbon to which R2 and R3 attach, forms C3-C7 cycloalkyl or C3-C7 heterocycloalkyl, either of which is optionally substituted with one or more substituents chosen from hydroxyl, halogen, and C1-C6 alkyl;
• or the C3-C7 cycloalkyl or C3-C7 heterocycloalkyl is fused with a phenyl ring which is optionally substituted with one or more substituents chosen from hydroxyl, halogen, and C1-C6 alkyl;
• Y is chosen from C and O;
• R4 is chosen from
• R5 and R6 are each independently C1-C6 alkyl;
• R7, R8, R9, and R10 are independently chosen from hydrogen and hydroxyl, or is independently chosen from C1-C6 alkyl and C1-C6 alkyloxy, either of which is optionally substituted with methoxy;
• p is 1 or 2;
• and
• X is chosen from C, O, or NR11 where R11 is hydrogen or C1-C3 alkyl;
• with the proviso that if A is thiophene, n is 2 or 3, R1 is hydrogen, and R4 is
• then either R5 and R6 are not both methyl, and/or R2 and R3 are not both methyl, and further provided that if A is thiophene, n is 2 or 3, R1 is hydrogen, and R4 is
• then R2 and R3 are not hydrogen.