Alcohol derivatives as Kv7 potassium channel openers

A method of treating a patient in the need thereof suffering from mania, acute stress reactions, bipolar depression, major depression, anxiety, panic attacks, social phobia, chronic pain, neuropathy, autism spectrum disorders, Huntington's chorea, or sclerosis, comprising administering to the patient a therapeutically effective amount of a compound of Formula (I):

• wherein
• R1 is selected from the group consisting of C1-C6 alkyl, CF3, CH2CF3, CF2CHF2, and C3-C8 cycloalkyl, wherein said C3-C8 cycloalkyl may be substituted with 1 or 2 F, CHF2 or CF3, and
• R2 is H, C1-C6 alkyl or CF3;
• or
• R1 and R2 combine to form C3-C5 cycloalkyl optionally substituted with 1 or 2 F, CHF2 or CF3;
• R3 is C1-C3 alkyl or CH2O—C1-3 alkyl, wherein said C1-C3 alkyl or CH2O—C1-3 alkyl may be optionally substituted with 1 or 2 F;
• and
• R4 is selected from the group consisting of CF3, OCF3, OCH2CF3 and OCHF2.