Compounds and methods for treatment of bacterial infections

A compound or a pharmaceutically acceptable salt thereof, wherein the compound is represented by Formula I,

• wherein:
• R1 in each instance independently is hydrogen or C1-10alkyl, wherein the C1-10alkyl is optionally substituted with one or more selected from the group consisting of a halogen, oxo (═O), OH, OC1-4alkyl, SC1-4alkyl, and arylC1-6alkyl;
• R2, R3, R4, and R5 are each independently selected from the group consisting of hydrogen, fluorine, chlorine, bromine, C1-4alkyl, CN, C1-6alkylCONH, C1-6alkylNHCO, C1-6alkylSO2NH, C1-6alkylNHSO2, and C1-6alkylSO2;
• X is O, S, NH or CH2;
• and
• Z in each instance independently is C or N, provided that:
• when a Z is N, the substituent R2, R3, R4, or R5 attached thereto is void;
• and
• when each Z is C, at least one of R2, R3, R4, and R5 is chlorine or fluorine.