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US 12,257,433 B2Granted
Methods for assessing efficacy of renal neuromodulation and associated systems and devices
AssigneeMedtronic Ireland Manufacturing Unlimited Company
InventorsCarol Sullivan, Stefan Tunev
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Abstract
Provided herein are methods, devices and compositions for assessing neuromodulation efficacy based on changes in the level of one or more biomarkers in plasma or urine collected from a human subject following a renal neuromodulation procedure.
Claims19
A method of assessing efficacy of a renal neuromodulation procedure in a human subject, the method comprising:
- at least partially ablating tissue via a catheter positioned in a renal vessel of the human subject, wherein the renal neuromodulation procedure includes at least partially ablating the tissue via the catheter positioned in the renal vessel;
- determining a post-neuromodulation level of one or more biomarkers following the renal neuromodulation procedure, wherein the level of the one or more biomarkers directly or indirectly correlate with sympathetic nervous activity in the human subject;
- comparing the post-neuromodulation level to a pre-determined level or range of levels for the one or more biomarkers;
- and
- classifying the renal neuromodulation procedure as at least partially successful based on the comparison, wherein one or more of the biomarkers are selected from the group consisting of vanillylmandelic acid and homovanillic acid.
2 more elements
Dependencies are inferred from the claim text.