Dynamic adjustment of algorithms for separation and collection of blood components

A blood processing system, comprising:

• a blood separation device including
• a separator configured to receive a blood separation chamber,
• a pump system, and
• a controller configured to control the separator and the pump system to execute a blood separation procedure having a target yield of at least one target blood component using an initial target amount of blood from a blood source, with execution of the blood separation procedure resulting in an actual yield of said at least one target blood component;
• and
• a data processing system configured to communicate with the controller, wherein
• the data processing system is configured to
• access or calculate the difference between a plurality of actual yields and target yields for blood separation procedures executed for a plurality of different blood sources,
• select two or more of said differences,
• determine an average of said two or more differences,
• determine an adjusted target amount of blood to be processed when executing the blood separation procedure for a subsequent blood source or a scaling factor to be applied when determining the adjusted target amount of blood to be processed when executing the blood separation procedure for said subsequent blood source based at least in part on said average, and
• transmit said adjusted target amount of blood or said scaling factor to the controller when the blood separation device is to be used to execute a blood separation procedure for said subsequent blood source and the controller is further configured to control the separator and the pump system to execute said blood separation procedure for said subsequent blood source, with the initial target amount of blood being replaced with said adjusted target amount of blood.