Biomaterials for biological tissue repair
AssigneeKonan Gakuen
InventorKoji Nagahama
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Abstract
The present provides a biomaterial for repairing biological tissues, the biomaterial comprising: a water-soluble polymer having a reactive functional group A; and a cell having tissue-regenerating capacity and having, on the surface thereof, a reactive functional group B that can covalently bind to the reactive functional group A, wherein the biomaterial presents a hydrogel state when the reactive functional group A covalently binds to the reactive functional group B. Thus, the present invention can provide a biomaterial for repairing biological tissues that can exert excellent effect in repairing biological tissues by utilizing a hydrogel encapsulating cells having tissue-regenerating capacity.
Claims16
A method for repairing a biological tissue, comprising:
- applying to an affected site a biomaterial comprising
- a water-soluble polymer having a reactive functional groups A;
- and
- mesenchymal stem cells having tissue-regenerating capacity and having, on the surface of the cells, reactive functional groups B that can covalently bind to the reactive functional groups A,
- wherein the biomaterial presents a hydrogel state when the reactive functional groups A covalently bind to the reactive functional groups B,
- wherein the water-soluble polymer is a polysaccharide thickener, and
- wherein the mesenchymal cells having tissue-regenerating capacity serve as cross-linking points of the hydrogel for chemically binding with the water-soluble polymer, wherein the affected site to which the biomaterial is applied is selected from the group consisting of (i) epithelial tissue, (ii) connective tissue adjacent to epithelial tissue, and (iii) skeletal muscle tissue.
A method for repairing a biological tissue, comprising:
- applying to an affected site a biomaterial in a form of a liquid or sol, wherein said biomaterial forms a hydrogel after application to said affected site, said biomaterial comprising
- a water-soluble polymer having a reactive functional groups A;
- and
- mesenchymal stem cells having tissue-regenerating capacity and having, on the surface of the cells, reactive functional groups B that can covalently bind to the reactive functional groups A,
- wherein the biomaterial presents a hydrogel state when the reactive functional groups A covalently bind to the reactive functional groups B,
- wherein the water-soluble polymer is a polysaccharide thickener,
- wherein the mesenchymal cells having tissue-regenerating capacity serve as cross-linking points of the hydrogel for chemically binding with the water-soluble polymer,
- wherein said affected site to which the biomaterial is applied is selected from the group consisting of (i) epithelial tissue, (ii) connective tissue adjacent to epithelial tissue, and (iii) skeletal muscle tissue.
Dependencies are inferred from the claim text.